Supported projects

H201903 – HIV treatment with genetically modified T progenitors resistant to infection

Lymphoma is a common complication in HIV patients, often occurring in the first year after initiating antiretroviral therapy and treated with chemotherapy and hematopoietic stem cell transplantation. The laboratory had the idea to take advantage of it by genetically modifying the stem cells before the transplant to make them resistant to HIV infection and thus, cure the patient of his lymphoma and infection. A clinical trial is underway at the Necker-Enfants Malades Hospital (PI: Marina Cavazzana). In parallel, the laboratory has developed a culture system that makes it possible to produce T progenitors in 7 days, from stem cells. The project aims to optimally combine the production of T progenitors and genetic modification to ultimately treat, with these cells, HIV patients who have developed lymphomas and efficiently and rapidly reconstitute a functional and resistant T-cell lymphocyte compartment to HIV infection.