Supported projects

D202006 – Measurement of the hemoglobin mass of sickle cell patients treated by gene therapy using the “CO rebreathing” method

Scientific leader
Dr. Pablo Bartolucci

Sickle cell disease is a genetic disorder that causes red blood cells disfunction, reducing their lifespan and their ability to circulate in the vessels. This disease is characterized by a decrease of red blood cells number leading to anemia. This anemia can be aggravated by an increase in the plasma volume (liquid in which the red blood cells bathe) which is frequent in these patients. Accurate measurement of the patient’s total amount of red blood cells is therefore crucial to accurately assess the severity of their anemia and the effectiveness of treatments such as gene therapy. However, this measurement cannot be performed by a blood test. This scientific project aims to test a new non-invasive, semi-automated technique to measure patients’ blood mass and thus determine whether their gene therapy treatment improves their anemia.



Team 2 Pirenne, U955

IMRB (Institut Mondor de Recherche Biomédicale)

5 rue Gustave Eiffel

94 017 Créteil