Supported projects

D202004 – Effect of hypoxia on erythroid differentiation in sickle cell disease

Scientific leader
Dr. Wassim El Nemer

Erythropoiesis is the differentiation process that results in the production of red blood cells from hematopoietic stem cells. It takes place in the bone marrow in humans, in a hypoxic environment, i.e. poor in oxygen. Our recent data show that this hypoxia could alter erythropoiesis in patients with sickle cell disease, an inherited hemolytic anemia due to a mutation that generates an abnormal hemoglobin that polymerizes in hypoxic conditions, causing abnormal shaped red blood cells. The HYPODIF project aims to acquire a “hypoxia box” which will allow cells culture in vitro under controlled oxygenation conditions. This equipment will be particularly useful in the context of sickle cell gene therapy in order to analyze the efficacy of therapeutic approaches in conditions transplanting the gaseous environment of the human bone marrow.



Team 1 UMR_S1134

INTS (Institut National de Transfusion Sanguine)

6 rue Alexandre Cabanel

75015 Paris