Brain imaging in children
The development of advanced techniques of neuro-imaging supplied new ways to examine the cortex and the white matter. These new techniques allow to measure in a non-invasive way the cerebral blood flow (ASL; arterial labelling spin); the intra and extra cellular oedema (diffusion); to study the connections of fibers (Tractography, DTI- tensor imaging, resting state).
These multimodal sequences of imaging also allow to measure parameters which can be followed in time (under treatment).
We are going to perform multimodal imaging before and after gene therapy in various pathologies (sickle cell disease, neurodegenerative diseases, mitochondrial or the ataxia of Freidreich).